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  • Blood Test

Vitamin B12 Active (Cobalamin) Blood Test

£55.00

5/5 from 221+ verified Google reviews

Tests for essential nutrients and diet-related factors.

Booking details

Overview

The Vitamin B12 Active (Cobalamin) test is a precise blood screening that measures the biologically active form of vitamin B12, known as holotranscobalamin (holoTC). Unlike total B12 measurements, this test assesses the functional, cell-available fraction of B12, providing an earlier and more reliable indicator of deficiency. Vitamin B12 is crucial for red blood cell production, neurological health, DNA synthesis, and homocysteine metabolism. Early detection of low active B12 levels can prevent irreversible nerve damage, anemia, cognitive decline, and cardiovascular risks associated with elevated homocysteine.

Key Test Components

Active Vitamin B12 Markers

Active Vitamin B12 (Holotranscobalamin / Cobalamin)

Sample Requirements

Sample Type:

Venous blood sample drawn

Fasting Required:

Not required (can be done at any time)

Why You Might Need This Test

Symptoms:

  • Persistent fatigue, weakness, or unexplained anemia
  • Numbness, tingling, or "pins and needles" in hands and feet
  • Difficulty with balance, walking, or coordination
  • Memory problems, confusion, irritability, or depression
  • Glossitis (inflamed tongue) or mouth ulcers

Health Screenings:

  • Routine nutritional assessment for vegans, vegetarians, or elderly adults
  • Annual screening for individuals over 50
  • Pre-treatment evaluation for fatigue or neurological complaints

Family & Medical History:

  • Family history of pernicious anemia or autoimmune disorders
  • Gastrointestinal conditions (celiac disease, Crohn's, gastric surgery)
  • Long-term use of acid-reducing medications (PPIs, metformin)
  • Chronic alcoholism or eating disorders

Ongoing Monitoring:

  • Evaluating response to vitamin B12 supplementation or injections
  • Tracking levels in malabsorption syndromes or post-bariatric surgery
  • Monitoring neurological or hematological conditions

Can’t Find Your Test?

If you can’t find the test you’re looking for, simply give us a call and our support team will guide you to the right option. We’re here to ensure you get the correct test quickly and confidently.

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Swift Blood Tests nurse visiting a client at home
5.0 ★★★★★ 221 Google reviews

Great service. I’m not the best with needles, however, Jo made me feel comfortable and at ease which made the whole process much more tolerable. 5 stars from me.

Chris C. Google review · ★★★★★
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