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The Lupus Anticoagulant Test is a specialised blood screening that detects the presence of lupus anticoagulant antibodies, which are a type of antiphospholipid antibody. Despite its name, lupus anticoagulant is not exclusively associated with lupus (systemic lupus erythematosus), nor does it cause bleeding—in fact, it increases the risk of abnormal blood clot formation. This test is essential for diagnosing antiphospholipid syndrome (APS), a significant autoimmune condition that causes excessive blood clotting in arteries and veins, leading to serious complications including stroke, deep vein thrombosis (DVT), pulmonary embolism, and recurrent pregnancy loss.
Mathematical ratios comparing screening and confirmatory test results to definitively identify lupus anticoagulant presence according to international diagnostic criteria.
Comprehensive analysis following International Society on Thrombosis and Haemostasis (ISTH) guidelines, determining whether lupus anticoagulant is positive, negative, or indeterminate based on the complete testing algorithm.
Venous blood sample
2 working days (specialised coagulation testing requiring careful
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The lupus anticoagulant test looks for an antibody that makes blood take longer to clot in a laboratory test, even though in the body it is linked with a higher risk of clots. Doctors may request it after a blood clot, during investigations for recurrent pregnancy loss, or when another clotting test gives an unexpected result.
Despite the name, this is not a test for lupus (SLE). It is a specialist clotting-related test, and results are interpreted by a clinician, often alongside a repeat test.
Anticoagulant medicines such as warfarin, heparin, apixaban and rivaroxaban can affect this test. Do not stop or change any medicine to have it — speak to the clinician who prescribed it about timing, and mention your medicines when you book.
Lupus anticoagulant only, from one blood sample. This is not a full antiphospholipid panel. If you need a general clotting check instead, see the clotting blood test.
No. The name is historical: the antibody was first noticed in people with lupus, but most people with lupus anticoagulant do not have lupus, and the test does not diagnose it.
In a test tube it slows clotting, which is how it got its name. In the body, it is associated with a higher risk of blood clots. That is why it is checked after unexplained clots.
Lupus anticoagulant is one of the antibodies checked for antiphospholipid syndrome, which can be linked with recurrent pregnancy loss. Your clinician will decide whether it is relevant to you.
Yes. Warfarin, heparin and newer anticoagulants can cause false-positive or unreliable results. Tell the person booking your test which medicines you take.
No. Never stop an anticoagulant on your own — it can be dangerous. If timing matters, your prescriber will advise you.
Antibodies can appear temporarily, for example after an infection. For antiphospholipid syndrome, a positive result usually needs to be confirmed on a second test at least 12 weeks later.
Yes. Recent infections and some medicines can cause a short-lived positive result, which is another reason clinicians repeat the test.
Clinicians usually also check anticardiolipin antibodies and anti-beta-2 glycoprotein I antibodies. This test covers lupus anticoagulant only.
DRVVT (dilute Russell's viper venom time) is one of the laboratory methods commonly used to look for lupus anticoagulant. You may see it named on your report.
A positive result does not on its own mean you have antiphospholipid syndrome. Your GP may arrange a repeat test or refer you to a haematology specialist.
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