Prostate Cancer Risk (HOXB13 variant) – Swift Blood Tests

£115.00

4.9/5 from 131+ verified Google reviews

  • Results: ~3 working days
  • Doctor’s report included
  • Convenient home or clinic sampling
  • Free delivery & returns

Biomarkers

This genetic test focuses on the HOXB13 gene, specifically variants like G84E, which are associated with increased prostate cancer risk[1]. It detects rare germline mutations that may elevate lifetime risk[2].

Sample collection: A small blood or saliva sample is taken using a simple kit at home or in one of our UK clinics. Our kit includes everything needed; simply return the sample in the pre-paid envelope. Results include a personalised doctor’s interpretation and recommendations.

Booking details

Age restriction: Adults 18+ only (guardian consent required for minors).

Overview

Prostate cancer risk testing for the HOXB13 variant is a targeted genetic screen that identifies mutations linked to hereditary prostate cancer[1][2]. It helps assess familial risks, particularly in men with early-onset or aggressive disease. Your doctor may recommend this if you have a family history of prostate cancer. Swift Blood Tests processes samples rapidly, with results and a doctor’s report typically within a few days.

Key Test Components

HOXB13 Gene Analysis

screens for pathogenic variants, such as G84E, which can increase prostate cancer risk by up to 8-fold or more[1].

Variant Detection

identifies whether the change is pathogenic, increasing risks for early-onset or aggressive prostate cancer[2].

Sample Requirements

A blood sample (collected in a purple-top EDTA tube) or saliva sample (using a provided collection tube) is required. No special patient preparation (such as fasting) is needed[4]. Simply drink water and eat normally unless otherwise instructed. Send samples via the next-day laboratory service.

Clinical Uses

Evaluate hereditary risk

For men with family histories of prostate cancer[1][3].

Guide screening

Positive results may prompt earlier or more frequent PSA tests and biopsies.

Inform management

Can influence decisions on active surveillance, surgery, or targeted therapies.

Family testing

Results may lead to screening relatives.

Why You Might Need This Test

You may be advised to take HOXB13 testing if you have any of the following signs or risk factors: - Family history: Multiple relatives with prostate cancer, especially diagnosed young. - Personal history: Early-onset prostate cancer. - Ethnic or genetic factors: Higher prevalence in certain populations. For example, a man with a father and brother affected by prostate cancer may carry the variant[3]. Your doctor will interpret results with your history.

Can’t Find Your Test?

If you can’t find the test you’re looking for, simply give us a call and our support team will guide you to the right option. We’re here to ensure you get the correct test quickly and confidently.

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FAQs

Frequently Asked Questions

What is Prostate Cancer Risk (HOXB13 variant) Testing?

This test checks for mutations in the HOXB13 gene that increase prostate cancer risk[1].

Recommended for those with family histories of prostate cancer to assess inherited risks[2][3].

 No special preparation required[4]. Eat and drink normally.

 Blood from a vein or saliva collection. Quick and minimal discomfort.

 Very low[5]; possible slight bruising from blood draw.

 Within 2–3 working days, with a doctor’s report.

 Yes, via home kit or clinic.

 DNA-based, so unaffected by external factors[6].

 Indicates higher prostate cancer risk; may lead to enhanced screening[3].

 For adults (18+); consult for minors.

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