Coeliac Disease – Tissue Transglutaminase IgA (Genetic and Antibody Tests) – Swift Blood Tests

£115.00

4.9/5 from 131+ verified Google reviews

  • Results: ~7 working days
  • Doctor’s report included
  • Convenient home or clinic sampling
  • Free delivery & returns

Biomarkers

This combined test measures IgA tissue transglutaminase (tTG) antibodies for immune response to gluten, along with genetic typing for HLA-DQ2 and HLA-DQ8 genes. It also checks for endomysial antibodies (EMA) and total IgA to rule out deficiency.

Sample collection: A small blood sample is taken (usually serum tube) by a finger-prick kit at home or in one of our UK clinics. Our kit includes everything needed; simply return the sample in the pre-paid envelope. Results include a personalised doctor’s interpretation.

Booking details

Age restriction: Adults 18+ only (guardian consent required for minors).

Overview

The coeliac disease test combines antibody and genetic screening to diagnose or rule out coeliac disease, an autoimmune disorder triggered by gluten. It checks for antibodies produced in response to gluten and genetic markers present in most affected individuals. Your doctor may order this test if you have symptoms like diarrhoea, bloating, or fatigue. The test helps identify the condition early to prevent complications like nutrient deficiencies. Swift Blood Tests processes samples rapidly, with results and a doctor’s report typically within 7 working days.

Key Test Components

Tissue Transglutaminase IgA (tTG-IgA)

detects antibodies indicating an immune reaction to gluten.

Endomysial Antibodies (EMA)

supportive test for coeliac confirmation.

HLA-DQ2/DQ8 Genetic Typing

identifies risk genes; absence rules out coeliac in most cases.

Total IgA

checks for IgA deficiency, which can cause false negatives.

Sample Requirements

A venous blood sample is required (collected in a gold-top serum tube). For antibody tests, continue eating gluten (in more than one meal a day) for at least 6 weeks prior; no preparation needed for genetic component. Drink water and eat normally otherwise. Send samples via the next-day laboratory service.

Clinical Uses

Screen for coeliac

In symptomatic individuals or at-risk groups like those with family history or autoimmune conditions.

Confirm diagnosis

Positive antibodies often lead to biopsy; genetics help in ambiguous cases.

Rule out coeliac

Negative HLA genes virtually exclude the disease.

Monitor adherence

Falling antibody levels indicate compliance with gluten-free diet.

Why You Might Need This Test

You may be advised to take a coeliac disease test if you have any of the following signs or risk factors: - Symptoms of coeliac: Chronic diarrhoea, abdominal pain, bloating, weight loss, or anaemia. - Family history or associated conditions: Relatives with coeliac, type 1 diabetes, or thyroid disease. - Unexplained nutrient deficiencies: Such as low iron or vitamin D. - Skin issues: Like dermatitis herpetiformis. For example, a patient with persistent bloating after eating bread may have positive tTG-IgA. Similarly, someone with family history might have risk genes. Your doctor will interpret the results alongside your history and may order a biopsy based on the findings.

Can’t Find Your Test?

If you can’t find the test you’re looking for, simply give us a call and our support team will guide you to the right option. We’re here to ensure you get the correct test quickly and confidently.

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FAQs

Frequently Asked Questions

What is a Coeliac Disease Test?

It includes antibody tests (like tTG-IgA) for gluten reaction and genetic tests (HLA-DQ2/DQ8) to assess risk or rule out coeliac disease.

 It is often ordered for symptoms like diarrhoea or fatigue, family history, or related conditions. It helps diagnose or exclude coeliac.

Eat gluten daily for 6 weeks before antibody testing. No preparation for genetics. If part of multiple tests, your provider will advise.

A small blood sample is taken from a vein in your arm using a needle. It is quick (often under 5 minutes) and routine. You may feel a brief pinch; afterwards, a bandage is applied. There are minimal risks.

Risks are very low. You might experience slight pain or bruising at the needle site, which usually resolves quickly.

Results are typically available within 7 working days. Swift Blood Tests provides a detailed doctor’s report explaining your results. You will be notified by email or phone as agreed.

 Yes. Swift Blood Tests offers a convenient home sample collection kit (finger-prick or small tube) with instructions, or you can choose a clinic appointment. Follow the included instructions to collect and return the sample by post.

Not eating gluten can cause false negatives in antibodies. IgA deficiency may require alternative tests. Mention diet or conditions to the doctor.

Positive antibodies suggest coeliac; genetics indicate risk. Your doctor may recommend a biopsy or gluten-free diet.

his test is intended for adults (18+). Children’s values differ. If needed for a child, please consult with a paediatric specialist or contact us for guidance.

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