£115.00
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Results: ~3 working days
doctor’s report included
Convenient home or clinic sampling
Free delivery & returns
This genetic panel tests for mutations in mismatch repair (MMR) genes including MLH1, MSH2, MSH6, PMS2, and sometimes EPCAM[1]. It identifies germline variants that cause Lynch syndrome, leading to defective DNA repair and increased cancer risks[2].
Sample collection: A small blood or saliva sample is taken using a simple kit at home or in one of our UK clinics. Our kit includes everything needed; simply return the sample in the pre-paid envelope. Results include a personalised doctor’s interpretation and genetic counselling recommendations.
Age restriction: Adults 18+ only (guardian consent required for minors).
Lynch syndrome testing, also known as hereditary nonpolyposis colorectal cancer (HNPCC) panel, is a genetic screening that evaluates key MMR genes for mutations associated with increased risks of colorectal, endometrial, and other cancers[1][2]. It helps diagnose or confirm Lynch syndrome, enabling early intervention[3]. Your doctor may recommend this if you have a family history of bowel cancer or related symptoms. Swift Blood Tests processes samples rapidly, with results and a doctor’s report typically within a few days.
mutations here account for about 40% of Lynch cases and increase risks for colorectal (up to 80%) and endometrial cancer (up to 60%)[1].
responsible for around 40% of cases, with similar high risks for colorectal and other cancers[1].
less common but associated with moderate to high risks, particularly for endometrial cancer[2].
assessed if relevant, as they can silence MSH2 expression.
categorises findings as pathogenic, likely pathogenic, benign, or uncertain[2].
A blood sample (collected in a purple-top EDTA tube) or saliva sample (using a provided collection tube) is required. No special patient preparation (such as fasting) is needed[4]. Simply drink water and eat normally unless otherwise instructed. Send samples via the next-day laboratory service.
Confirming mutations in MMR genes for those with suspicious cancer histories[1][3].
Guides screening for colorectal, endometrial, ovarian, and other associated cancers[2].
Positive results may lead to regular colonoscopies, hysterectomies, or other preventive measures.
Mutations can influence cancer therapies, such as immune checkpoint inhibitors.
You may be advised to take Lynch syndrome testing if you have any of the following signs or risk factors: - Family history: Multiple relatives with colorectal, endometrial, ovarian, or urinary tract cancers, especially under age 50. - Personal history: Early-onset bowel cancer or multiple primary cancers. - Tumour screening: Abnormal results from microsatellite instability (MSI) or immunohistochemistry (IHC) tests on tumours. - Other indicators: Known Lynch syndrome in relatives. For example, someone with colorectal cancer diagnosed before 50 may carry an MMR mutation[3]. Similarly, a woman with endometrial cancer might benefit from testing. Your doctor will interpret the results alongside your history and may order additional tests based on the findings.
If you can’t find the test you’re looking for, simply give us a call and our support team will guide you to the right option. We’re here to ensure you get the correct test quickly and confidently.
This is a genetic panel that checks for mutations in genes like MLH1, MSH2, MSH6, and PMS2, which cause Lynch syndrome and increase risks for bowel and other cancers[1].
It is recommended for those with a family or personal history of colorectal or related cancers to assess inherited risks and guide screening[2][3].
No special preparation is usually required[4]. You can eat and drink normally. Genetic counselling is advised before and after.
A small blood sample is taken from a vein in your arm, or a saliva sample is collected using a swab or spit kit. It is quick and routine. You may feel a brief pinch if blood is drawn; afterwards, a bandage is applied. There are minimal risks.
Risks are very low[5]. Slight pain or bruising may occur at the needle site for blood draws. Saliva collection has no risks.
Results are typically available within 2–3 working days. Swift Blood Tests provides a detailed doctor’s report explaining your results. You will be notified by email or phone as agreed.
Yes. Swift Blood Tests offers a convenient home sample collection kit (saliva or finger-prick blood) with instructions, or you can choose a clinic appointment. Follow the included instructions to collect and return the sample by post.
Results are DNA-based, so not affected by lifestyle[6]. Mention family history or prior tests to the doctor.
A pathogenic mutation indicates Lynch syndrome and higher cancer risks, but not certainty of cancer[3]. Follow-up may include enhanced screening.
Testing minors requires specialist consultation; contact us for guidance.
